I guarantee you that it will work with any MIDI module you use, the Zendrum when it is all said and done is simply a MIDI controller. It is no different if you are using a TD-6V module with the older 3 series chip, or the new Z4 chip, it will still send that MIDI signal to your module and trigger that sound that is assigned to that MIDI number. I am getting mine upgraded next week and I assure you, if there was any doubt that it would or wouldn't work with any module I plug it into, I would NOT be getting the upgrade. The advantages to getting the upgrade is now you can add up to 6 more triggers, and it is more sensitive in response. There are other features in how you can set up your Zendrum now as well within the programs, like the save function, and you can get the Zenedit program and really use the crossfade function if you are using a module. I can't see any reason not to get the upgrade. I was a little hesitant myself, but after our gathering last August, and hearing and seeing the new Z4 chip that some others had (and some persuasion by Inspector 109), I am going to just do it. I am not nervous at all, it will work with whatever I hook it up to and it will work flawlessly. JUST DO IT!!!!!