I use about 4 basic setups, and they vary a lot, being what may be tambourine on one kit is shaker on another, even though its the same setup on the ZD. This way, changing kits gives me versatility as well as changing setups.
My basic setup for regular 'kit' playing is this:
My right hand rests on Bass1, with fingers tapping Snare1 and HH close/open. This allows the left hand to play clave and claps while running tom fills without stopping the basic rhythm. I have another setup where those toms are congas/bongos, to run percussion under basic grooves.
The left hand can also reach under to ghost the snare, or pull double bass riffs off of Bass2, which is tuned differently to avoid "machine gunning".
It becomes very simple to move the hand up or over to switch to rides and even change the snare. This setup basically allows the right hand to ride (on ride1, ride2, hh, cowbell, tamb, whatever) and play the bass1 and either snare1 or snare2 depending on position, while the left hand does perc/toms. Right hand also gets control of accents with the crashes and the stuff way at the tail end. This is done mostly for theatrics. If you just rush your hand from the crashes to the splash/vibraslap section, it looks real cool to end a song.
I usually play HH/S1/B1 one handed or B1/S2/R2 1 handed. If I ride right on pretty much any piece, the left hand sneaks under for B2/S1 riffing.
And that's my primary of 4 setups. Another is the latin perc one, another has snares ane basses run where there toms are and all of the tail being rides, literally to stretch the arms if playing live, and another is a hybrid of some of these, allowing a two handed riding, with a tambourine/shaker at both left and right hand. Again, on some kits, my Splash might be a whistle or such, but its always a high end accent, so I don't have to know the exact kit, but I know the utility of the sound.
Of course, there are some songs that abandon all this and just go another way altogether.
Hope that gives you something to chew on.