Avast Thar Mateys,
Methinks that while it may be enjoyable to play the Zendrum while driving, me also thinks that such an endeavour is akin to putting on makeup while driving. Not exactly the sort of thing you want to do. Remember the second law of sea - Safety First! unless of course you are in the passenger seat. If such is the case and someone else is driving (presuming he/she is also not playing an instrument at the time), then Zen on!
Fair Winds and Following Seas,